Surgical Treatment of Patients With Lynch Syndrome

For individuals with Lynch syndrome who develop a colon cancer, a total colectomy is preferred for cancer risk reduction. (1B)

Patients with Lynch syndrome who develop a colon cancer may consider segmental colectomy despite the inferior cancer risk reduction because of differences in bowel function between segmental and total colectomy. (2C)

Annual colonoscopy should be performed after segmental resection of colon cancer in patients with Lynch syndrome. (1B)

For patients with Lynch syndrome and rectal cancer, the rectal cancer should be treated based on standard oncologic principles, as in sporadic rectal cancer. The decision for concomitant colectomy may be considered on a selective basis. (2C)

Hysterectomy and bilateral salpingo-oophorectomy should be offered to women with Lynch syndrome undergoing colectomy, particularly if they have finished childbearing. (1B)