Endoscopic Eradication Therapy for Patients with Barrett’s Esophagus–Associated Dysplasia and Intramucosal Cancer

Publication Date: February 1, 2018
Last Updated: March 14, 2022


1. In BE patients with LGD and HGD being considered for EET, we suggest confirmation of diagnosis by at least 1 expert GI pathologist or panel of pathologists compared with review by a single pathologist. (C, L)

2a. In BE patients with LGD, we suggest EET compared with surveillance; however, patients who place a high value on avoiding adverse events related to EET may choose surveillance as the preferred option. (C, M)
2b. In BE patients with confirmed HGD, we recommend EET compared with surveillance. (S, M)

3. In BE patients with HGD/IMC, we recommend against surgery compared with EET. (S, VL)

4. In BE patients referred for EET, we recommend endoscopic resection of all visible lesions compared with no endoscopic resection of visible lesions. (S, M)

5. In BE patients with visible lesions who undergo endoscopic resection, we suggest ablation of the remaining Barrett’s segment compared with no ablation. (C, L)

6. In BE patients with dysplasia and IMC referred for EET, we recommend against routine complete endoscopic resection of entire Barrett’s segment compared with endoscopic resection of visible lesion followed by ablation of remaining Barrett’s segment. (S, VL)

7. In BE patients with dysplasia and IMC who have achieved CE-IM after EET, we suggest surveillance endoscopy versus no surveillance. (C, VL)

BE, Barrett’s esophagus; EET, endoscopic eradication therapy; HGD, high-grade dysplasia; LGD, low-grade dysplasia; IMC, intramucosal cancer; CE-IM, complete eradication of intestinal metaplasia

Recommendation Grading




Endoscopic Eradication Therapy for Patients with Barrett’s Esophagus–Associated Dysplasia and Intramucosal Cancer

Authoring Organization

Endorsing Organization

Publication Month/Year

February 1, 2018

Last Updated Month/Year

June 7, 2023

Document Type


External Publication Status


Country of Publication


Inclusion Criteria

Female, Male, Adolescent, Adult, Child, Infant, Older adult

Health Care Settings

Hospital, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Management, Treatment

Diseases/Conditions (MeSH)

D001471 - Barrett Esophagus, D004938 - Esophageal Neoplasms, D001997 - Bronchopulmonary Dysplasia


dysplasia, Barrett’s esophagus, intramucosal cancer