In this post, we will be taking a closer look at some of the most popular endocrinology-related articles recently published across medical journals.

Thyroidectomy without radioiodine in patients with low-risk thyroid cancer: 5 years of follow-up of the prospective randomised ESTIMABL2 trial

  • The Lancet Diabetes & Endocrinology
  • January 2025
  • The ESTIMABL2 trial, a multicenter randomized phase 3 study involving patients with low-risk differentiated thyroid cancer (specifically, pT1am or pT1b, N0 [no evidence of regional nodal involvement] or Nx [involvement of regional lymph nodes that cannot be assessed in the absence of neck dissection]), has demonstrated the non-inferiority of a follow-up strategy that does not involve the administration of radioactive iodine (I) when compared to a postoperative I administration at the 3-year mark post-randomization. In this report, we present a pre-specified analysis conducted after 5 years of follow-up.
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Bile acid metabolism in type 2 diabetes mellitus

  • Nature Reviews. Endocrinology
  • January 2025
  • Type 2 diabetes mellitus is a multifaceted condition characterized by insulin resistance and inadequate levels of insulin to regulate glucose metabolism effectively. The alterations in insulin signaling and insulin levels are believed to be the primary drivers of the metabolic abnormalities observed in diabetes mellitus, including impaired glucose disposal. However, it is also recognized that molecules impacted by abnormal insulin signaling may trigger secondary metabolic effects that further exacerbate the pathology of type 2 diabetes mellitus. Recent research has shed light on the relationship between insulin resistance and the concentration, composition, and distribution of bile acids. Bile acids play a crucial role in regulating glucose metabolism, lipid metabolism, and energy balance, suggesting that they may serve as mediators of metabolic dysfunction in type 2 diabetes mellitus. This emerging evidence underscores the importance of understanding the intricate interplay between bile acids and insulin resistance in metabolic regulation.
  • In this review, the aim is to elucidate the complex mechanisms underlying the regulation of bile acids during insulin resistance and explore the contribution of bile acids to metabolic homeostasis.
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Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database

  • Diabetes Care
  • February 2025
  • The objective of this study was to evaluate the enhanced predictive capability of incorporating a type 2 diabetes (T2D) polygenic risk score (PRS) alongside family history in T2D prediction. The results indicated that including a T2D PRS, in conjunction with a family history of T2D among first-degree relatives, significantly improved the statistical accuracy of T2D prediction. Further research is warranted to ascertain the potential clinical utility of integrating both family history and a PRS in T2D prediction.
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Cardiometabolic Aspects of Congenital Adrenal Hyperplasia

  • Endocrine Reviews
  • January 2025
  • The treatment of classic congenital adrenal hyperplasia (CAH) focuses on replacing deficient hormones and reducing excess androgens. Despite advancements in early diagnosis and lifelong hormonal therapy, individuals with CAH still face numerous complications and an increased risk of mortality. This article aims to provide a comprehensive and balanced review of the cardiometabolic risks associated with CAH.
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Effects of stevia consumption on appetite in adults: A systematic review and dose–response meta-analysis of randomized controlled trials

  • Obesity Reviews
  • January 2025
  • Stevia is a potent, calorie-free sweetener commonly utilized to decrease caloric consumption. Despite its widespread use, research on the effects of stevia on appetite and energy intake has yielded conflicting results, leaving a definitive conclusion elusive. This systematic review and meta-analysis seeks to elucidate the influence of stevia on appetite and energy intake in adult populations.
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Inter-organ communication is a critical machinery to regulate metabolism and aging

  • Trends in Endocrinology & Metabolism
  • December 2024
  • Inter-organ communication (IOC) is a sophisticated mechanism crucial for maintaining metabolic balance and promoting healthy aging. Disruption of various forms of IOC has been associated with metabolic disorders and age-related diseases, highlighting the potential for targeting these processes in therapeutic interventions aimed at enhancing healthy aging.In this comprehensive review, we explore the intricate network of IOC facilitated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks, and their significant roles in regulating metabolism and aging. Of particular importance is the hypothalamus, known as a central control center for aging and longevity, and its communication with peripheral organs.
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Novel Detection and Progression Markers for Diabetes Based on Continuous Glucose Monitoring Data Dynamics

  • Journal of Clinical Endocrinology & Metabolism
  • December 2024
  • Traditional static measures of continuous glucose monitoring (CGM) data, such as time spent in specific glucose ranges (70-180 mg/dL or 70-140 mg/dL), are limited in their ability to fully capture the dynamic nature of glucose levels. This is especially true when it comes to detecting the subtle gradual deterioration of glycemic control over time in individuals with early-stage type 1 diabetes. In order to address this limitation, CGM dynamics markers have emerged as a promising alternative to traditional methods like fasting plasma glucose or glucose tolerance testing. These markers offer a more comprehensive and nuanced understanding of an individual's glucose fluctuations, allowing for earlier identification of those at higher immunological risk of progressing to type 1 diabetes.
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There you have it - a look at some of the most popular endocrinology articles recently released. Sign up for alerts and stay informed on the latest published guidelines and articles.

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