Consistent engagement with current medical literature enables clinicians to apply the latest evidence-based treatment and integrate research into clinical practice. This approach enhances patient outcomes by facilitating more effective and individualized care.
Today, we’re showcasing some of the latest thyroidology-related articles published recently across medical journals. The topics in today’s rundown include hypothyroidism and Graves’ disease.
Hypothyroidism Topics
An Unusual Presentation of Severe Hypothyroidism in a Child With Undiagnosed Systemic Lupus Erythematous
- JCEM Case Reports, December 2025
- Description: [The authors’] present a case of a 13-year-old girl diagnosed with autoimmune hypothyroidism who was started on 75 µg of levothyroxine by her general practitioner. She was referred to the endocrine clinic after six months of treatment for hypothyroidism with two months of worsening fatigue, chest pain, peripheral edema, and dyspnea.
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Transient Congenital Hypothyroidism with Normal Size Thyroid Caused by MAternal Thyrotropin Receptor Antibodies: A Case Report and Literature Review
- BMC Pregnancy and Childbirth, December 2025
- Description: This report describes a case of CH attributed to maternal elevated levels of thyroid-stimulating hormone receptor antibody (TRAb) with normal thyroid size, and further provides a systematic review of neonatal thyroid size classification in other CH cases from the literature.
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Myxedema Coma as the Initial Presentation of Undiagnosed Hypothyroidism: A Rare but Reversible Emergency
- Cureus, December 2025
- Description: Myxedema coma is a rare, life-threatening endocrine emergency representing the extreme manifestation of untreated hypothyroidism. It usually presents with nonspecific symptoms such as confusion, hypothermia, and bradycardia, which can lead to delayed recognition, particularly in elderly patients with multiple comorbidities.
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Graves’ Disease Topics
The Progression of TRAb-positive Subacute Thyroiditis and its Differential Diagnosis from Graves’ Disease
- Frontiers in Immunology, December 2025
- Description: Currently, studies on thyroid-stimulating hormone receptor antibody-positive subacute thyroiditis are relatively limited. Therefore, this article reviews the pathogenesis of thyroid-stimulating hormone receptor antibody-positive subacute thyroiditis and its differential diagnosis from Graves’ disease, aiming to enhance the understanding of this disease among clinicians.
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Graves’ Disease with Autoimmune Hepatitis and Primary Sclerosing Cholangitis: An Overlap Syndrome
- Oxford Medical Case Reports, December 2025
- Description: In patients presenting with both Graves' disease and hepatitis, the diagnostic challenge is to determine the cause of elevated liver enzymes. [The authors] present an 11-year-old girl with acute liver cell failure and cholestasis in a setting of untreated hyperthyroidism. She was diagnosed to have Graves' disease with AIH and primary sclerosing cholangitis.
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Delayed Severe Heart Failure Despite Successful Graves’ Disease Management
- Clinical Case Reports, December 2025
- Description: Patients with Graves' disease may develop delayed heart failure with reduced ejection fraction even after achieving biochemical euthyroidism. Vigilance for cardiac complications and early referral to cardiology are essential.
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Look forward to more journal-focused topics in the coming weeks.
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