Consistent engagement with current medical literature enables clinicians to apply the latest evidence-based treatment and integrate research into clinical practice. This approach enhances patient outcomes by facilitating more effective and individualized care.

Today, we’re showcasing some of the latest endocrinology-related articles published recently across medical journals. Today’s rundown focuses on hyperthyroidism and hypothyroidism topics, including autoimmune hyperthyroidism, acquired hypothyroidism, pediatric autoimmune hyperthyroidism, and more.

Hyperthyroidism Articles

The Free T3/Free T4 Ratio Predicts Relapse After Antithyroid Drug Withdrawal in Pediatric Autoimmune Hyperthyroidism

  • The Journal of Clinical Endocrinology and Metabolism, March 2026
  • Description: The likelihood of remission in patients with autoimmune hyperthyroidism (AH) depends on several prognostic factors. The free T3 (FT3)/free T4 (FT4) ratio has been suggested as a potential marker of disease severity and prognosis. [This study’s objective was] to evaluate the prognostic value of the FT3/FT4 ratio in predicting the likelihood of relapse in patients with AH.
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Hyper-Thyro Vision: An Integrated Framework for Hyperthyroidism Diagnostic Facial Image Analysis Based on Deep Learning

  • Biomimetics, March 2026
  • Description: This paper presents an integrated multi-modal framework for detecting hyperthyroidism-associated abnormalities, namely exophthalmos and thyroid-related neck swelling, through the joint analysis of frontal facial and neck images using a deep learning-based approach. The objective of this research is to develop an integrated AI framework that improves hyperthyroid-related abnormality detection by simultaneously analyzing facial images of both the eye and neck based on pattern clinical knowledge.
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Maternal TSH-Receptor Antibodies Predict Fetal/Neonatal Hyperthyroidism in Pregnancies with a History of Graves Disease

  • The Journal of Clinical Endocrinology and Metabolism, March 2026
  • Description: Transplacental transfer of thyrotropin receptor antibodies (TRAbs) during pregnancy may cause fetal/neonatal thyroid dysfunction. Current guidelines recommend a universal TRAb titer threshold, irrespective of gestational age or assay platform. However, evidence supporting trimester-specific and assay-specific thresholds is lacking.
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Autoimmune Hyperthyroidism Following Haematopoietic Stem Cell Transplant for Multiple Sclerosis in an Adult Female: A Case Report and Literature Review

  • Endocrinology, Diabetes & Metabolism Case Reports, February 2026
  • Description: There is existing evidence to suggest that haematopoietic stem cell transplant has been linked to, in rare cases, autoimmune thyroid dysfunction. Much of the current literature highlights paediatric occurrences. The most common dysfunction noted is hypothyroidism, seen in 40% of cases, with other autoimmune thyroid dysfunctions reported less commonly. A 34-year-old female represents a unique case of autoimmune hyperthyroidism secondary to haematopoietic stem cell transplant completed for relapsing-remitting multiple sclerosis.
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Hypothyroidism Articles

Levothyroxine for Subclinical Hypothyroidism in Older Adults: No Evidence of Benefit on Quality of Life or Cardiovascular Outcomes: A Systematic Review

  • BMC Geriatrics, April 2026
  • Description: Subclinical hypothyroidism (SCH) is highly prevalent in older adults, yet the efficacy of levothyroxine treatment in this population remains uncertain. This systematic review evaluated the efficacy of levothyroxine compared with placebo or no treatment on health-related quality of life (HRQoL) and major adverse cardiovascular events (MACE) in older adults with mild SCH.
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Collateral Thyroid Damage: A Case Report of Suspected TKI-Induced Hypothyroidism

  • SAGE Open Medical Case Reports, March 2026
  • Description: Tyrosine kinase inhibitors (TKIs) are widely used in cancer therapy and are known to induce hypothyroidism in some patients, though the mechanisms remain unclear. [The authors] describe a 58-year-old man with metastatic gastrointestinal stromal tumor who developed clinical hypothyroidism during TKI treatment.
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A Review on Levothyroxine Therapy and Bone Age in Children with Long-Standing Untreated Acquired Hypothyroidism

  • Bioinformation, January 2026
  • Description: Children with long-standing untreated hypothyroidism often experience delayed bone maturation and impaired linear growth, which can persist even after the initiation of therapy. Therefore, it is of interest to review the effects of levothyroxine therapy on bone age advancement and growth outcomes in children with hypothyroidism.
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Changes in Bone Mineral Density Following Levothyroxine Therapy in Hypothyroidism – A Prospective, Observational Study

  • AACE Endocrinology and Diabetes, January 2026
  • Description: Thyroid hormones play a significant role in skeletal metabolism and bone turnover. We investigated the effect of levothyroxine (LT4) replacement on bone mineral density (BMD) using dual-energy x-ray absorptiometry in newly diagnosed patients with hypothyroidism.
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Look forward to more journal-focused topics in the coming weeks. 

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