Consistent engagement with current medical literature enables clinicians to apply the latest evidence-based treatment and integrate research into clinical practice. This approach enhances patient outcomes by facilitating more effective and individualized care.

Today, we’re showcasing some of the latest hematology-related articles published recently across medical journals. The topics in today’s rundown focus on hematologic disorders, specifically anemia, hemophilia, and thrombocytopenia.

Anemia Articles

Navigating Anemia Therapy in CKD: The Role of Hypoxia-Inducible Factor Activators

  • American Journal of Kidney Diseases, January 2026
  • Description: In this review, [researchers] examine the mechanisms of action and erythropoietic effects of HIF-PHIs, evaluate undesirable on-target and off-target effects, and address cardiovascular and other safety concerns that have been raised in comparison to ESAs. We discuss how this novel class of oral anemia drugs may impact clinical practice, including their potential use in kidney transplant recipients.
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The Effect of Air Pollution and Household Environmental Indicators on Anemia Status Among Under-Five Children in Low-Middle Income Countries: Exploring Potential Machine Learning Applications on Demographic and Health Surveys

  • Scientific Reports, January 2026
  • Description: Exposure to air pollution has been associated with anemia in children, but little effort has been made in low- and middle-income countries (LMICs) in which the prevalence of anemia is persistently high. This study aimed to assess the effects of air pollution and household environmental indicators on anemia among children aged 6–59 months using machine learning algorithms.
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Coagulation Abnormalities in Pediatric Anemia Clinical and Laboratory Correlates for Risk Stratification and Risk Assessment

  • Annals of Medicine and Surgery, January 2026
  • Description: This narrative review synthesizes current clinical and laboratory evidence on coagulation disturbances in pediatric anemia, highlighting their prevalence, pathophysiologic mechanisms, and clinical manifestations. Emphasis is placed on practical strategies for risk assessment, integrating standard laboratory evaluations - complete blood count, coagulation panel, and platelet function assays - with clinical features to identify children at highest risk for adverse outcomes.
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Hemophilia Articles

Redefining Hemophilia Management: Treatment Goals, Nonfactor Replacement Therapies, and the Role of Fitusiran

  • The American Journal of Managed Care, January 2026
  • Description: Hemophilia is a rare, but debilitating congenital bleeding disorder. Current therapeutic guidelines, last updated in 2020, recommend recombinant clotting factor concentrates as the standard replacement therapy, with emicizumab offered as an alternative nonfactor standard of care. Since the publication of those guidelines, approvals of new gene-based and nonfactor therapies have reshaped the therapeutic landscape. This supplement describes the safety and efficacy of those therapies approved after the 2020 guidelines were published.
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Joint Tissue Plasticity in Hemophilia: Insights from the Joint Activity and Damage Exam Ultrasound Protocol

  • Research and Practice in Thrombosis and Haemostasis, January 2026
  • Description: Progressive arthropathy is a debilitating condition that affects hemophilic joints as a consequence of hemarthroses. However, our understanding of the trajectory of potentially destructive processes at the tissue level remains limited and requires longitudinal imaging studies. To longitudinally characterize ultrasonographic joint tissue changes in adults with hemophilia using the Joint Activity and Damage Exam (JADE) protocol, and to examine their relationships with joint health status, hemarthrosis, and serum biomarkers of tissue turnover.
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Health Care Resources and Costs Associated with Delivering Gene Therapy for Hemophilia in Clinical Practice

  • Research and Practice in Thrombosis and Haemostasis, January 2026
  • Description: The debate around the cost-effectiveness of gene therapy for hemophilia has largely centered on its price (€1-€3.5 million per individual). While previous studies have explored care organization for gene therapy delivery, none have evaluated the potential resource utilization and associated costs in a real-world setting.
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Thrombocytopenia Articles

N-acetylcysteine Reduces Incidence and Duration of Linezolid-associated Thrombocytopenia in Critically Ill Patients: A Randomized Controlled Trial

  • Environmental Toxicology and Pharmacology, January 2026
  • Description: Linezolid-associated thrombocytopenia (LAT) limits its use in critically ill patients. This double-blind, randomized, placebo-controlled trial evaluated intravenous N-acetylcysteine (IV NAC) for LAT prevention in 250 critically ill adults receiving linezolid for ≥ 48 hours.
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Association Between Thrombocytopenia and Development of Acute Respiratory Distress Syndrome

  • Respiratory Research, January 2026
  • Description: Given that platelets support the integrity of the alveolar-capillary membrane, it is conceivable that thrombocytopenia may be associated with development of acute respiratory distress syndrome (ARDS). Yet, clinical studies confirming such an association are limited. [Researchers] endeavoured to examine whether thrombocytopenia is independently associated with development of ARDS in critically ill patients.
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Preoperative Thrombocytopenia and Risk of Periprosthetic Joint Infection After Total Knee Arthroplasty: A Propensity-Matched Cohort Study

  • The Journal of Arthroplasty, January 2026
  • Description: Periprosthetic joint infection (PJI) remains one of the most devastating complications following total joint arthroplasty (TJA). While platelets are recognized for their role in hemostasis, growing evidence suggests they also serve as immune effectors. Experimental data support a link between platelet depletion and infection risk, yet clinical evidence is limited.
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Look forward to more journal-focused topics in the coming weeks. 

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