Today, we are looking into the latest active, currently recruiting, phase 2 clinical trials focused on aphasia. This series aims to offer a glimpse into upcoming innovations and research, and how the outcomes of clinical trials could potentially influence clinical guidelines related to aphasia.
The following list features active, currently recruiting phrase 2 clinical trials related to aphasia. Please note that the dates provided are approximate and subject to change.
| Study Title | Phase | Enrollment | Start Date | Last Post Updated |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia | 2 | 63 | 8/1/24 | 5/13/25 |
| Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia | 2 | 24 | 2/11/25 | 2/18/25 |
| Communication Bridge 3 Study | 2 | 200 | 8/23/24 | 5/29/25 |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia | 2 | 180 | 2/13/24 | 1/2/25 |
| Escitalopram and Language Intervention for Subacute Aphasia | 2 | 88 | 7/18/21 | 11/8/24 |
Currently Recruiting, Phase 2 Clinical Trials
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
- Sponsor: University of Pennsylvania
- Goal: To determine if Transcranial Magnetic Stimulation combined with modified constraint induced language therapy is an effective treatment for aphasia when delivered in the subacute stage after stroke.
- Interventions: Transcranial Magnetic Stimulation
- Primary Outcome Measures: Overall language function
- Timeframe: From Baseline to 4 months post-interventions
- Study Details
- Source
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
- Sponsor: University of Pennsylvania
- Goal: The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation combined with speech-language therapy is an effective treatment for mild aphasia in persons with chronic stroke.
- Interventions: Transcranial Magnetic Stimulation
- Primary Outcome Measures: Sentence Processing
- Timeframe: From baseline to 4 months post-intervention
- Study Details
- Source
Communication Bridge 3 Study
- Sponsor: University of Chicago
- Goal: The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with primary progressive aphasia.
- Interventions: Communication Bridge™, Evidence-Based Impairment Focused
- Primary Outcome Measures: Change in communication participation person centered goals / change in communication participation / Montgomery Burden Inventory
- Timeframe: 5 assessment time points through study completion (up to 18 months)
- Study Details
- Source
Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
- Sponsor: Johns Hopkins University
- Goal: In this study, scientists in the three sites that have conducted tDCS clinical trials in North America-Johns Hopkins University and the University of Pennsylvania in the US, and the University of Toronto in Canada, will collaborate to conduct a multi-site, Phase II clinical trial of tDCS a population in dire need of better treatments.
- Interventions: Active tDCS + Language Therapy, Sham tDCS + Language Therapy
- Primary Outcome Measures: Immediate change in phonemic accuracy / immediate change in letter accuracy / change in phonemic accuracy at 3-month follow-up visit / change in letter accuracy at 3-month follow-up visit
- Timeframe: Three weeks / three weeks / three months / three months
- Study Details
- Source
Escitalopram and Language Intervention for Subacute Aphasia
- Sponsor: Johns Hopkins University
- Goal: The investigators will investigate the effects of a selective serotonin reuptake inhibitor, escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).
- Interventions: Escitalopram 10mg, placebo, computer-delivered naming treatment
- Primary Outcome Measures: Change in Philadelphia Naming Test short-form accuracy score.
- Timeframe: Baseline, 1 week after computer-delivered naming treatment
- Study Details
- Source
Potential Guidelines That May Be Affected Include:
Clinical Practice Guideline for Management of Stroke Rehabilitation
- Department of Veterans Affairs / Department of Defense
- 2024
- Summary
Guidelines for Adult Stroke Rehabilitation and Recovery
- American Heart Association / American Stroke Association
- 2017
- Summary
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