Management of Metastatic Renal Clear Cell Cancer

Publication Date: October 9, 2023
Last Updated: October 10, 2023

Diagnosis

Recommendation 1.1

The diagnosis of metastatic clear cell renal cell carcinoma should ideally involve comparison of tissue acquired outside the site of primary disease to the primary histology. Histologic evaluation should include common markers of clear cell renal cell carcinoma including paired box gene 8 (PAX8) and Carbonic anhydrase IX (CAIX). (EB, B, H, S)
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Treatment

Recommendation 2.1

Select patients (see Practical Information) with metastatic clear cell renal cell carcinoma may be offered cytoreductive nephrectomy.a (EB, B, H, S)
Practical Information: Select patients include those with optimally 1 International Metastatic RCC Database Consortium (IMDC) risk factor who can have a significant majority of their tumor burden removed at the time of surgery.
a See Figure 1: First-line treatment.
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Overview

Title

Management of Metastatic Renal Clear Cell Cancer

Authoring Organization