Clear Cell Renal Cell Carcinoma
Key Points
Key Points
- Kidney cancer will be diagnosed in 79,000 U.S. patients in 2022 and will account for 13,920 deaths.
- Opportunities for extended survival and even durable disease control in the metastatic setting have recently appeared as novel classes of therapeutics, reshaping the trajectory of this cancer.
- This rapid evolution has paved the way for this first set of comprehensive guidelines for treating metastatic clear cell renal cell carcinoma (ccRCC).
Diagnosis
...agnosis...
....1The diagnosis of metastatic clear cell...
...commendation 1.2Radiographic diagnosis of metastat...
Treatment
...eatmen...
...ecommendation 2.1Select patients (see Practical...
...ommendation 3.1Select patients with...
...1. First-Line Treatmenta Select case...
...ndation 3.2All patients with metastat...
...dation 3.3Patients with favorable risk dise...
...ation 3.4Select patients with metastatic...
...3.5The use of high dose interleukin-2 (HD-IL2)...
...ommendation from 2023 Rapid Recommendation Update...
...mendation 3.6Treatment with IpiNivoCabo is no...
...ion 4.1Nivolumab or cabozantinib should be offere...
...ecommendation 4.2Patients progressing on c...
...endation 4.3Patients who progress after initial...
...tion 4.4For patients on immunotherapy who e...
...ion 5.1For patients with low volume metastat...
...ommendation 5.2For patients undergoin...
....1.1Patients with symptomatic bone metas...
Recommendation 6.1.2Patients with bon...
...gure 2. Second-Line or Greater...
...Metastases-Directed Treatment
...6.1.3No recommendation regarding optimal sy...
...ommendation 6.2.1Patients with brain metastases fr...
...mmendation 6.2.2No recommendation regarding op...
...ion 6.3Patients with metastatic clear cell...
.... Special Patient Subtypes
...ASCO believes that cancer clinical trials are vita...