Pharmacological Management of Irritable Bowel Syndrome With Constipation
Summary of Recommendations
In patients with IBS-C, the AGA suggests using tenapanor ( Moderate , Conditional (weak) )
612
In patients with IBS-C, the AGA suggests using plecanatide ( Moderate , Conditional (weak) )
612
In patients with IBS-C, the AGA recommends using linaclotide ( High , Strong )
612
In patients with IBS-C, the AGA suggests using tegaserod ( Moderate , Conditional (weak) )
Implementation remark: Tegaserod was reapproved for women under the age of 65 years without a history of cardiovascular ischemic events (such as myocardial infarction, stroke, TIA, or angina)
612
In patients with IBS-C, the AGA suggests using lubiprostone ( Moderate , Conditional (weak) )
612
In patients with IBS-C, the AGA suggests using PEG laxatives ( Low , Conditional (weak) )
612
In patients with IBS, the AGA suggests using TCAs ( Low , Conditional (weak) )
612
In patients with IBS, the AGA suggests against using SSRIs ( Low , Conditional (weak) )
612
In patients with IBS, the AGA suggests using antispasmodics ( Low , Conditional (weak) )
612
Recommendation Grading
Overview
Title
Pharmacological Management of Irritable Bowel Syndrome With Constipation
Authoring Organization
American Gastroenterological Association
Publication Month/Year
June 21, 2022
Document Type
Guideline
Country of Publication
US
Document Objectives
Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline.
Inclusion Criteria
Male, Female, Adult, Older adult
Health Care Settings
Ambulatory
Intended Users
Nurse, nurse practitioner, physician, physician assistant
Scope
Treatment, Management
Diseases/Conditions (MeSH)
D043183 - Irritable Bowel Syndrome
Keywords
irritable bowel syndrome (IBS), IBS, IBS-C, irritable bowel syndrome with constipation