Irritable Bowel Syndrome With Constipation
Publication Date: June 21, 2022
Key Points
Key Points
- Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with worse health-related quality of life (QOL) than patients with diabetes or end-stage renal disease.
- Its worldwide prevalence among adults is between 4.1% (Rome IV criteria) and 10.1% (Rome III criteria). IBS is most common in women and younger individuals, particularly IBS with constipation (IBS-C).
- IBS with predominant constipation (IBS-C) is a subtype of IBS.
- A positive diagnosis of IBS-C can be made on the basis of medical history and physical examination, evaluation of gastrointestinal symptoms (especially alarm signs), limited diagnostic testing, and use of the symptom-based Rome IV criteria.a
- The presence of alarm features — such as new symptom onset after age 50 years; rectal bleeding not attributable to hemorrhoids or anal fissures; unintentional weight loss; iron deficiency anemia; nocturnal diarrhea; and a family history of colon cancer, inflammatory bowel disease, or celiac disease — requires more patient-specific investigations.
a Kellow JE, Drossman DA, Chang L, et al, eds. Rome IV Diagnostic Algorithms for Common GI Symptoms. 2nd ed. Rome Foundation, 2016.
Treatment
...Treatment...
...Food and Drug Administration (FDA)-approved Drug...
...Patients Wi...
...tients with IBS-C, the AGA suggests...
...th IBS-C, the AGA suggests using plecanatide. ( Mo...
...h IBS-C, the AGA recommends using linaclotide....
...th IBS-C, the AGA suggests using te...
...with IBS-C, the AGA suggests using lubiprost...
...nts with IBS-C, the AGA suggests u...
...Patients With IBS...
...nts with IBS, the AGA suggests using tricyc...
...ts with IBS, the AGA suggests against using...
...h IBS, the AGA suggests using antispasmodics. (...