Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy

Authoring Organization

Publication Month/Year

November 1, 2021

Last Updated Month/Year

October 17, 2023

Document Type


External Publication Status


Country of Publication


Target Patient Population

Adult patients with cancer receiving treatment with immune checkpoint blockade inhibitors alone.

Target Provider Population

Oncologists, medical specialists, emergency medicine, family practitioners, nurses, and pharmacists

Inclusion Criteria

Male, Female, Adolescent, Adult, Child, Older adult

Health Care Settings

Ambulatory, Emergency care, Hospital, Outpatient

Intended Users

Healthcare business administration, nurse, nurse practitioner, community pharmacist, health systems pharmacist, physician, physician assistant


Management, Prevention

Diseases/Conditions (MeSH)

D007167 - Immunotherapy, D064420 - Drug-Related Side Effects and Adverse Reactions, D000082082 - Immune Checkpoint Inhibitors


immune checkpoint inhibitor (ICI), Immune Checkpoint Inhibitor, Immune-Related Adverse Events, IRAEs, Cancer immunotherapy, Keytruda, Opdivo, ICPis

Source Citation

Schneider BJ, Naidoo J, Santomasso BD, Lacchetti C, Adkins S, Anadkat M, Atkins MB, Brassil KJ, Caterino JM, Chau I, Davies MJ, Ernstoff MS, Fecher L, Ghosh M, Jaiyesimi I, Mammen JS, Naing A, Nastoupil LJ, Phillips T, Porter LD, Reichner CA, Seigel C, Song JM, Spira A, Suarez-Almazor M, Swami U, Thompson JA, Vikas P, Wang Y, Weber JS, Funchain P, Bollin K. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. J Clin Oncol. 2021 Dec 20;39(36): 4073-4126. doi: 10.1200/JCO.21.0.1440. Epub 2021 Nov 1. Erratum in: J Clin Oncol. 2022 Jan 20;40(3):315. PM ID: 34724392

Supplemental Methodology Resources

Data Supplement


Number of Source Documents
Literature Search Start Date
August 30, 2017
Literature Search End Date
March 2, 2021
Specialties Involved
Dermatology, Emergency Medicine, Endocrinology, Family Medicine, Gastroenterology, Hematology, Internal Medicine General, Oncology, Rheumatology, Medical Oncology, Hematology Oncology, Oncology, Hematology