Today, we’re showcasing some of the latest pediatric research published within medical journals during the first few weeks of September 2025. The articles cover a wide range of topics, including oncology, cardiology, ophthalmology, and other key areas of pediatric health.

For clinicians, keeping up with emerging evidence is essential. Not only does doing so inform treatment strategies, but it also helps ensure pediatric patients receive care supported by the most up-to-date data. By regularly reviewing published research, clinicians are better equipped to incorporate findings into the care they deliver to patients, particularly regarding the unique needs of young patients.

The following eight articles, published within the first three weeks of September 2025, represent just a small sampling of pediatric research articles published during this period.

Simultaneous Native Right Nephrectomy and Extraperitoneal Pediatric Kidney Transplantation Using the Same Incision for Both Surgeries

  • Transplantation Proceedings, September 2025
  • Description: Kidney transplantation is the best option for pediatric patients with end-stage kidney disease but remains challenging due to donor-recipient size mismatch. The intraperitoneal approach is associated with high morbidity, while the extraperitoneal approach is safer and more feasible. The latter approach often requires performing a native kidney nephrectomy to create sufficient space for graft placement. Clinical outcomes following simultaneous native right nephrectomy and extraperitoneal kidney transplantation through the same incision in pediatric recipients were assessed.
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Mechanistic Models Position Ceritinib as a Nuclear Integrity Disrupting Therapy in Pediatric Liver Tumors

  • Journal of Experimental & Clinical Cancer Research, September 2025
  • Description: Pediatric liver tumors with high-risk features pose therapeutic challenges, necessitating the development of more targeted and effective treatment strategies. Computational modeling of virtual patients and in silico drug response simulations, based on properly trained mechanistic models, is a powerful strategy to predict new treatment options. We aimed to leverage patient-specific mechanistic cell models to identify therapeutic alternatives for pediatric patients with high-risk liver tumors.
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Breastfeeding on ART and a Closer Look at Drug Transfer to HIV-exposed Uninfected Infants

  • Scientific Reports, September 2025
  • Description: Adherence to antiretroviral therapy (ART) and maintaining an undetectable maternal HIV viral load effectively prevent intrauterine and perinatal HIV transmission. However, concerns remain regarding the safety of breastfeeding in infants exposed to maternal ART. This retrospective study analyzed eight breastfed HIV-exposed uninfected (HEU) infants who were followed from January 2015 to July 2022.
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Histological Guided Treatment in Paediatric Patients Presenting with Severe Left Ventricular Dysfunction

  • European Journal of Pediatrics, September 2025
  • Description: Differential diagnosis in children presenting with dilated cardiomyopathy and severe cardiac dysfunction is challenging. In [the researchers’] hospital, a protocol was established in 2015 in which endomyocardial biopsy (EMB) was performed in selected patients and treatment was guided by biopsy results. The study aims to describe [the researchers’] experience with this diagnostic and therapeutic strategy. We performed a unicenter paediatric ambispective study that include patients with dilated cardiomyopathy and severe cardiac dysfunction (left ventricular ejection fraction (LVEF) < 35%) in whom EMB was performed and treatment was prescribed based on EMB results from February 2015 to December 2024.
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Bilateral Implantation of a Non-diffractive Extended Depth of Focus Intraocular Lens in Pediatric Patient with Lamellar Cataract

  • International Ophthalmology, September 2025
  • Description: A 13-year-old boy with bilateral lamellar cataract underwent standard phacoemulsification and bilateral implantation of a toric, non-diffractive EDOF IOL. Preoperative assessment included biometry, keratometry, and visual acuity testing. Postoperative follow-up included refraction, defocus curve, contrast sensitivity, and patient-reported outcomes.
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Balancing Benefit and Burden: Treatment Intensification in Paediatric KMT2A Rearrangements Acute Myeloid Leukaemia

  • Acta Oncologica, September 2025
  • Description: Chromosomal rearrangements involving KMT2A (KMT2A-r) occur in 20% of paediatric acute myeloid leukaemia (AML). Previous studies reported that the outcome depends on the specific fusion partner. The study aimed to report the outcomes of paediatric KMT2A-r AML patients and to assess the impact of different fusion partners. Patient/material and methods: [Researchers] retrospectively analysed 610 paediatric patients with intermediate-risk (IR) AML diagnosed at Children's Cancer Hospital Egypt, from January 2008 to December 2021.
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Current Practices and Trends in Surgical Decision-making for Children with Lennox-Gastaut Syndrome: A Cross-sectional Survey by the Pediatric Epilepsy Research Consortium

  • Epilepsia Open, September 2025
  • Description: The objective of this study is to characterize contemporary surgical management practices and factors influencing surgical decision-making in the management of Lennox–Gastaut Syndrome (LGS) across pediatric epilepsy centers in the United States.
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Pediatric Angioedema Without Urticaria: A Rare Presentation of Autoimmune Thyroid Disease with Complete Remission on Levothyroxine Therapy

  • Journal of Postgraduate Medicine, September 2025
  • Description: Angioedema without urticaria (AEwU) is an uncommon manifestation of autoimmune thyroid disease (AITD), rarely reported in the pediatric population. AEwU secondary to AITD is a diagnosis of exclusion and should be considered in patients with unexplained angioedema after ruling out hereditary and allergic causes.
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Look forward to more journal-focused topics in the coming weeks. 

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