In this post, we will be taking a closer look at some of the most popular endocrinology-related articles that have been published during the month of April 2024.

The American Society for Bone and Mineral Research Task Force on clinical algorithms for fracture risk report

  • Journal of Bone and Mineral Research
  • 4/9/2024
  • Using race and ethnicity in clinical algorithms potentially contributes to health inequities. The American Society for Bone and Mineral Research (ASBMR) Professional Practice Committee convened the ASBMR Task Force on Clinical Algorithms for Fracture Risk to determine the impact of race and ethnicity adjustment in the US Fracture Risk Assessment Tool (US-FRAX).
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2024 Abridged Diabetes Standards of Care

  • Diabetes Technology & Therapeutics
  • 4/15/2024
  • This collection provides an abridged version of the American Diabetes Association’s (ADA’s) Standards of Care in Diabetes—2024 designed especially for primary care professionals. Developed by the ADA’s Primary Care Advisory Group, this new resource contains the evidence-based clinical practice recommendations most pertinent to primary care—all presented in a user-friendly format.
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Impact of insulin sensitization on metabolic and fertility outcomes in women with polycystic ovary syndrome and overweight or obesity—A systematic review, meta-analysis, and meta-regression

  • Obesity Reviews
  • 4/4/2024
  • Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. This systematic review, meta-analysis, and meta-regression aims to compare the effect of insulin sensitizer pharmacotherapy on metabolic and reproductive outcomes in women with PCOS and overweight or obesity.
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Effectiveness of interventions to reduce social inequalities of weight status in adolescents: A systematic review and meta-analysis

  • Obesity Reviews
  • 4/21/2024
  • Many interventions are implemented in the public health context to overcome social inequalities of weight status in adolescents, but their effectiveness is challenged. This study aimed to examine the effectiveness of these interventions with a systematic review and meta-analysis.
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Efficacy and Safety of Tirzepatide in Overweight and Obese Adult Patients with Type 1 Diabetes

  • Diabetes Technology & Therapeutics
  • 4/21/2024
  • We assessed the use of tirzepatide in OW/OB subjects with T1D. In this pilot (off label) study, we conclude that tirzepatide facilitated an average 18.5% weight loss (>46 pounds) and improved glucose control in OW/OB patients with T1D at 1 year. For safe use of tirzepatide in patients with T1D, we strongly recommend a large prospective randomized control trial in OW/OB patients with T1D.
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Association Between Treatment Adherence and Continuous Glucose Monitoring Outcomes in People With Diabetes Using Smart Insulin Pens in a Real-World Setting

  • Diabetes Care
  • 4/3/2024
  • This combined analysis of real-world smart pen and CGM data showed that missing two basal or four bolus insulin doses over a 14-day period would be associated with a clinically relevant decrease in TIR. Smart insulin pens provide valuable insights into treatment injection behaviors.
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Efficient vascular and neural engraftment of stem cell-derived islets

  • Diabetes
  • 4/11/2024
  • Pluripotent stem cell-derived islets (SC-islets) now emerge as a new source for beta-cell replacement therapy. While the function of human islet transplants is hampered by excessive cell death post-transplantation, contributing factors include inflammatory reactions, insufficient revascularization and islet amyloid formation, there is a gap in knowledge on the engraftment process of the SC-islets. In this experimental study, we investigated the engraftment capability of SC-islets at three months post-transplantation.
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A spatiotemporal proteomic map of human adipogenesis

  • Nature Metabolism
  • 4/2/2024
  • White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generate a spatiotemporal proteomic atlas of human adipogenesis, which elucidates cellular remodelling as well as the spatial reorganization of metabolic pathways to optimize cells for lipid accumulation and highlights the coordinated regulation of protein localization and abundance during adipocyte formation.
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Continuous glucose monitoring for the routine care of type 2 diabetes mellitus

  • Nature Reviews Endocrinology
  • 4/8/2024
  • Although continuous glucose monitoring (CGM) devices are now considered the standard of care for people with type 1 diabetes mellitus, the uptake among people with type 2 diabetes mellitus (T2DM) has been slower and is focused on those receiving intensive insulin therapy.
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Endocrine health in survivors of adult-onset cancer

  • Lancet Diabetes and Endocrinology
  • 4/8/2024
  • This review highlights common symptoms and conditions related to endocrine disorders among survivors of adult-onset cancer, provides a summary of the currently available practice guidelines, and proposes a practical approach to diagnose affected patients among this group.
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A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice

  • Journal of Clinical Lipidology
  • 4/1/2024
  • Since the 2019 National Lipid Association (NLA) Scientific Statement on Use of Lipoprotein(a) in Clinical Practice was issued, accumulating epidemiological data have clarified the relationship between lipoprotein(a) [Lp(a)] level and cardiovascular disease risk and risk reduction. Therefore, the NLA developed this focused update to guide clinicians in applying this emerging evidence in clinical practice.
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Cardiovascular Outcomes of KCNJ5 mutated Aldosterone-Producing Adenoma: A Systematic Review

  • Endocrine Practice
  • 4/22/2024
  • This systematic review provided evidence of the significant association between KCNJ5 mutation and unfavorable cardiovascular outcomes in patients with primary aldosteronism. Further research is needed to improve the quality of evidence on this topic and elucidate the underlying mechanisms of the potential burden of KCNJ5 mutation.
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Decision Regret Following the Choice of Surgery or Active Surveillance for Small, Low-Risk Papillary Thyroid Cancer: A Prospective Cohort Study

  • Thyroid
  • 4/8/2024
  • In 2016, we introduced AS as an alternative to immediate surgery within a Canadian prospective research study on disease management choice in patients with small, low-risk PTC. This study builds on our prior work, in its aim to examine the level of decision regret about a year after our patients made the decision to accept immediate surgery or AS. Decision regret is a distressing emotion, which may be experienced following a life decision, and it may be associated with negative patient perceptions regarding decision satisfaction, quality of life, health outcomes, and health care system experience. We also examined the level of fear of disease progression, anxiety, depression, quality of life, and perceived body image relative to treatment choice, at one-year follow-up.
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Cystatin C is a predictor for long-term All-Cause and Cardiovascular Mortality in US Adults with Metabolic Syndrome

  • Journal of Clinical Endocrinology & Metabolism
  • 4/10/2024
  • This study examined the relationship between Cystatin C (CysC) levels and all-cause, CVD, and cancer mortality in US metabolic syndrome (MetS) patients.
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Substituting carbohydrate at lunch for added protein increases fat oxidation during subsequent exercise in healthy males

  • Journal of Clinical Endocrinology & Metabolism
  • 4/13/2024
  • How pre-exercise meal composition influences metabolic and health responses to exercise later in the day is currently unclear. Our objective is to examine the effects of substituting carbohydrate for protein at lunch on subsequent exercise metabolism, appetite, and energy intake.
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There you have it – a look at some of the most popular endocrinology publications released in April 2024. Sign up for alerts and stay informed on the latest published guidelines and articles.


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