- Colorectal cancer (CRC) screening should begin at age 50 years in asymptomatic persons.
- Colonoscopy every 10 years and annual fecal immunochemical test (FIT) are currently the first considerations for screening.
- A risk-stratified approach is also appropriate, with FIT screening in populations with an estimated low prevalence of advanced neoplasia and colonoscopy screening in high prevalence populations.
GRADE Strength of Recommendations and Implications
|Grade||Quality of Evidence|
We are very conﬁdent that the true effect lies close to that of the estimate of the effect.
We are moderately conﬁdent in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Our conﬁdence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect.
We have very little conﬁdence in the effect estimate. The true effect is likely to be substantially different from the estimate of effect.
|Grade||Strength of Recommendation|
|For the Patient||For the Clinician|
Most individuals in this situation would want the recommended course of action and only a small proportion would not.
The majority of individuals in this situation would want the suggested course of action, but many would not.