Somatic Genomic Testing for Metastatic or Advanced Cancer

Published: February 2022
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  • Key Points
  • Tables 
    • Select Definitions of Commonly Used Terms in Precision Oncology
    • Selected Genetic Alterations Linked to FDA Approvals as of June 2021
  • Select Definitions of Commonly Used Terms in Precision Oncology
    • Multigene Panel-Based Genomic Sequencing with Disease-Specific Approved Markers
    • Assessment of dMMR and/or MSI-H Status, and TMB
    • Testing for Gene Fusions and Exon Skipping Variants
    • Diseases with No Approved Disease-Specific Markers
    • Elements to Consider While Reviewing Genomic Testing Results
    • Additional Topics
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Founded in 1964, the American Society of Clinical Oncology is the world's leading professional organization for physicians and oncology professionals caring for people with cancer.


This pocket guide is derived from recommendations in the American Society of Clinical Oncology Guideline. This resource is a practice tool based on ASCO® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. This pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. The practice guidelines and additional information are available at Copyright © 2022 by American Society of Clinical Oncology. All rights reserved.


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